Protocol for the examination of specimens from patients with carcinomas of the major salivary glands. New developments in salivary gland pathology archives of. Two 2014 publications have added further possible candidates with molecular abnormalities to the list cribriform adenocarcinoma of the tongue and minor salivary glands and epithelialmyoepithelial carcinoma, but these findings have yet to be confirmed by other investigators. Salivary gland sg progenitor cells sgpcs maintain sg homeostasis. This is a wellwritten chapter with a thorough description of various epithelial tumors of practical importance in dental pathology. Attempts are being made to identify effective therapeutic agents for salivary duct carcinomas by using molecular diagnostic techniques. When they occur in this anatomic area, these tumors. At the same time that ancillary testing is improving our ability to diagnose salivary gland tumors, our understanding of the biology and molecular characteristics of these tumors. Salivary gland pathology an overview sciencedirect topics. Selected recent advances in the pathology of salivary. As such, in the presence of limited tissue sampling that typifies the initial testing modalities, including fine needle aspiration biopsy andor incisional biopsy, it often is not possible to differentiate a benign from malignant minor salivary gland. Role of immunohistochemical markers in salivary gland. Recently, there have been significant developments in our understanding of salivary gland pathology, and new entities, such as mammary analogue secretory carcinoma, have been described.
Defining the role of myoepithelium in salivary gland. Sclerosing polycystic adenosis is a rare lesion often mistaken histo logically for carcinoma. Alena skalova tomas vanecek roderick hw simpson michal michal abstract. Recent advances in the diagnostic pathology of salivary. Molecular advances in salivary gland pathology and their practical application. Salivary glands primary salivary gland neoplasms malignant. Common, 5 10% of salivary gland tumors 6 10% of salivary gland malignancies, 17% of parotid gland malignancies, 15% of minor salivary gland malignancies sites.
There are three pairs of major salivary glands under the tongue and near the ears and jawbones, and hundreds of small salivary glands in the mouth, nose, and larynx. Whats new in salivary gland cancer research and treatment. Salivary gland disease includes a wide range of unique and rare conditions that are treated by ear, nose and throat ent, oral and maxillofacial surgeons omfs and oral medicine specialists. Atlas of salivary gland pathology focuses on the diagnostic approach to salivary gland neoplasiaone of the more challenging fields within surgical pathology emphasizing the need to understand downstream implications with respect to patient surveillance and treatment. Molecular investigation in salivary gland pathology is becoming common and can provide differential diagnostic, therapeutic and prognostic information important not only for the purpose of classification of tumours but also in management of patients with salivary gland carcinomas. Recently, there have been significant developments in our understanding of salivary gland pathology, and new entities, such as mammary. Advances in salivary gland pathology wiley online library. Immunohistochemical evaluation plays a vital role in the. Home salivary glands adenocarcinoma, not otherwise specified nos advertisement. Most colleagues in oral pathology and oral medicine work closely with the omfs but might have missed some of.
In each, the gene rearrangement is found in 80 % or more of cases. Salivary gland fine needle aspiration and introduction of. The major salivary glands are the paired parotid, submandibular, and sublin. Fine needle aspiration fna is a wellestablished procedure for the diagnosis and management of salivary gland lesions despite challenges imposed by their diversity, complexity, and. The classification of salivary gland tumors is rapidly evolving with description of new entities, such as mammary analogue secretory carcinoma masc. A vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, for several. Advances in salivary gland pathology in the application of immunohistochemistry, cd117 can aid in highlighting the luminal cell component of various salivary gland tumours, whereas p63 or maspin can aid in highlighting the abluminal cell component. Article pdf available in seminars in diagnostic pathology. Until recently, the reporting of salivary gland fna specimens was inconsistent among differe.
It can be seen rarely in head and neck region, such as oral cavity, trachea. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection. Salivary glands are frequently in the radiation field and are part of the collateral damage to normal tissues that occurs with radiation therapy. In recent days its incidence is gradually increasing worldwide. Histopathology of the salivary glands springerlink. For accreditation purposes, this protocol should be used for the following procedures and tumor types. Salivary gland cancer is a rare cancer that forms in the tissues of the salivary glands. Anatomically, 75% of sgcs are located in the parotid gland, although only 25%. Pitfalls in the biopsy diagnosis of intraoral minor. Salivary gland lesions oral surgery, oral medicine, oral pathology.
Recent advances and evolving concepts recently, there have been significant developments in our understanding of salivary gland pathology. Progression of salivary gland tumours can take the form of malignant transformation of a benign tumour, progression from lowgrade to highgrade carcinoma. Salivary gland cancer overview american association for. Firstly, there are three types of salivary gland carcinomas which harbour important oncogenic. Chemo drugs, often given along with radiation, are now being tested in clinical trials and may provide more options for people with advanced salivary gland cancer. The existence of primary salivary gland type tumors sgts, similar to those occurring in the major salivary glands, is well known in the thoracic cavity. Salivary glands may give rise to a wide spectrum of different tumors. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering. The next 2 chapters salivary gland tumors, written by r. Malignant salivary gland tumours represent about 5% of all head and neck cancers, with a slight predominance in men 54,55.
Physiology, pathology and regeneration of salivary glands. There is a vast range of conditions and controversies in the histopathological assessment of salivary gland diseases. Massachusetts general hospital harvard medical school, usa marc pusztaszeri, md, geneva, switzerland. Newly described salivary gland tumors modern pathology nature. A clinical approach to diagnosis and management of atypical and suspicious lesions w. In particular, newly recognized entities and specific chromosomal translocations associated with salivary gland carcinomas are discussed. Masses or cystic lesions of salivary glands have a wide range of differential diagnoses, from inflammatory response to neoplasm and to less common causes of infection. Pdf recent advances in the management of salivary gland. Histopathological diagnosis is pivotal to making a diagnosis and treatment planning. Hence, it is essential to diagnose the type and grade these neoplasms for early management.
Molecular advances in salivary gland pathology and their practical application article in diagnostic histopathology 189. Recent advances in the histopathological assessment of. Lassche g1, van boxtel w1, ligtenberg mjl2, van engenvan grunsven ach3, van herpen cml4. Salivary gland fine needle aspiration and introduction of the milan reporting system. Salivary gland diseases sgd are multiple and varied in cause there are three paired major salivary glands in humans the parotid glands, the submandibular glands, and the sublingual glands, and about 800 minor salivary glands in the mucosa of the mouth. The parotid gland is located in front of the ear, and it secretes its mostly serous saliva via the parotid duct. Advances and challenges in precision medicine in salivary gland cancer. Differentiation between these benign and malignant neoplasms is often predicated on the presence or absence of invasion. More than half of all salivary gland tumors are benign and do not spread to other tissues. Insights into a complex group of neoplastic disease. Molecular advances in salivary gland pathology and their practical. The field of salivaomics is then considered in detail, covering, for example, proteomics, the peptidome, dna and rna analysis, biomarkers, and methods for biomarker discovery. Due to routine immunization, the incidence of mumps has declined and sialolithiasis is the most frequent salivary gland pathology in most of the developed world.
Analysis of the clinical relevance of histological classification of. Fineneedle aspiration biopsy of salivary gland lesions. Advances in histopathologic classification and molecular pathology of salivary gland cancer ilmo leivo haartman institute, department of pathology, fin00014 university of helsinki, finland. This article will focus on some of the new advances in salivary gland tumor pathology that have a potential for. Though histopathological diagnosis is the gold standard for the investigation of various salivary gland neoplasms.
Abstract cancers of major and minor salivary glands represent a histopathologic challenge in two major. Molecular advances in salivary gland pathology and their. Selected recent advances in the pathology of salivary neoplasms. Recent molecular advances and diagnostic applications. Metastatic salivary gland cancer cancer thats spread to other parts of the body is rare, so knowledge about treating these cancers with chemotherapy chemo is still evolving. Here we discuss the role of neoplastic myoepithelium in the scope of salivary gland neoplasia and present this information from a practical diagnostic standpoint. Progenitor cell niche senescence reflects pathology of the. Recent advances in the diagnostic pathology of salivary carcinomas. Physiology, pathology and regeneration of salivary glands mdpi. Basic salivary gland pathology 1 basic salivary gland pathology jennifer l. The aetiology of the salivary gland tumour is mainly described by the multicellular theory, by which each cell type can give rise to a specific type of tumour table 1 56,57,58,59,60.
Skalova a, vanecek t, simpson rhw et al, molecular advances in salivary gland pathology and their practical application. Fine needle aspiration fna is a wellestablished procedure for the diagnosis and management of salivary gland lesions despite challenges imposed by their diversity, complexity, and cytomorphologic overlap. Newly described salivary gland tumors modern pathology. June 2017 includes ptnm requirements from the 8th edition, ajcc staging manual.
Evaluation of patients with suspected salivary gland. Recent advances in histopathology archives of pathology. Selected recent advances in the pathology of salivary neoplasms diagnostic histopathology. Most of these malignancies are squamous cell carcinomas scca and treated, at least in part with ionizing radiation 20. Advances in salivary gland pathology, histopathology 10. Salivary glands igg4 related dacryoadenitis and sialoadenitis mikulicz disease syndrome.
1040 824 1043 612 512 1277 671 321 1269 1311 690 910 1472 215 867 101 106 309 762 112 606 56 997 126 836 1383 421 1098 1297 1007 557 926 1097 1398 1028 1118 649 750 408 1007 315 750 663 1411 574